CC CHEMOKINE RECEPTOR 5, CC CHEMOKINE LIGANDS 3 AND 5 GENE POLYMORPHISMS IN PATIENTS WITH PERIODONTITIS- A CASE-CONTROL STUDY
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 172
- 试验地点
- 1
- 主要终点
- 1. The distribution of genotype and allele frequencies are to be assessed.
研究概览
简要总结
Genetic factors play a remarkable role in the predisposition and progression of periodontal disease. Hence it is plausible to hypothesize that the genetic polymorphisms of these chemokines and their receptor may predispose or protect the individuals from developing periodontitis. Hence the aim of the present study is to compare the association of CCR5 G59029A, CCL5 -28 C/G and CCL3 459 C/T gene polymorphisms in patients with periodontitis.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 30.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Systemically healthy patients of age 30-60 are to be recruited for the study.
- •Ethnic Tamilian subjects.
- •Control group to include subjects with no signs of periodontal disease and probing sulcus depth of ≤ 3mm with no evidence of clinical attachment loss.
- •Test group to include patients with Probing Pocket Depth of ≥ 5mm and/or Clinical Attachment Loss of ≥3mm in greater than 30% of sites with chronic periodontitis.
排除标准
- •Patients with any inflammatory systemic conditions such as diabetes mellitus, rheumatoid arthritis, etc.
- •Patients with immunodeficiency disorders.
- •Patients with local modifiers like food impaction, factitious habits and bruxism.
- •Patients who smoke.
- •Use of orthodontic and prosthetic appliances.
- •Patients who had taken systemic antibiotic, anti-inflammatory, hormonal or other assisted drug therapy in the last 6 months or prior to the study.
结局指标
主要结局
1. The distribution of genotype and allele frequencies are to be assessed.
时间窗: BASELINE
2. Plaque Index -PI (Loe and silness,1964)
时间窗: BASELINE
3. Modified Sulcular bleeding index -mSBI (Mombelli, 1987)
时间窗: BASELINE
4. Probing pocket depth (PPD)
时间窗: BASELINE
5. Clinical attachment level (CAL)
时间窗: BASELINE
次要结局
未报告次要终点