the Association Between Thyroid Hormones and Metabolic Components in Patients With Obesity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 373
- 主要终点
- meet the criteria of metabolism in the 2017 Chinese guideline
研究概览
简要总结
This study collected clinical data of obese patients with euthyroid function, including age, gender, height, weight, BMI, waist circumference, blood pressure, fasting blood sugar, blood sugar 2 hours after sugar load, fasting plasma high-density lipoprotein cholesterol, fasting three acyl glycerin, free iodine thyroid hormone (FT3) and free thyroid hormones (FT4), thyroid stimulating hormone (TSH), follow-up information and etc. Via analyzing the data, the investigators want to investigate the association between thyroid hormones (THs) and metabolic components in obese patients with euthyroid function and to present the cutoff values of THs in order to provide new information for the risk stratification of metabolic syndrome in obese patients with euthyroid function.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age ranged from 18-65 years old, 2) BMI over 27.9kg/m2,3)TSH，FT4, and FT3 within the range of 0.38-4.34mIU/L, 10.5-24.4mIU/L, and 2.8-6.3mIU/L, respectively.
排除标准
- •secondary cause of obesity such as hypothalamic obesity, Cushing syndrome, and hypophysis dysfunction, etc.,2)pregnancy or location, 3) severe heart, liver and kidney dysfunction
结局指标
主要结局
meet the criteria of metabolism in the 2017 Chinese guideline
时间窗: 2015-2020
1. Abdominal obesity (or central obesity), male abdominal circumference ≥90cm, female abdominal circumference ≥85 cm; 2. Hypertension, those who have been diagnosed with hypertension and are in treatment and (or) blood pressure ≥130/85mmHg (1mmHg = 0.133kPa); 3. Hyperglycemia, those who have been diagnosed with diabetes and are treated and (or) fasting blood glucose ≥6.1mmol/L or 2h blood glucose ≥7.8mmol/L after glucose load; 4. Fasting high-density lipoprotein cholesterol (HDL-C) \<1.04mmol/L; 5. Fasting triacylglycerol ≥1.70mmol/L.
次要结局
- FBG≥6.1mmol/L(2015-2020)
- FINS≥24.9 pmol/ml(2015-2020)
- FCP≥4.4nmol/L(2015-2020)
- high uric acid(2015-2020)
- BG120≥7.8mmol/L(2015-2020)
研究者
Shen Qu
Principal Investigator
Shanghai 10th People's Hospital