NCT01468493Unknown不适用
A Prospective Controlled Follow-up of Serum Soluble Urokinase Receptor in the Cyclosporine A-treated Patients With Steroid-dependent and Steroid-resistant Focal Segmental Glomerulosclerosis
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- serum suPAR level when proteinuria reduction >=50% or complete remission
研究概览
简要总结
The purpose of this study is to determine whether the improved responsiveness to treatment achieved by CsA in patients with steroid-resistant or steroid-dependent FSGS could be explained by CsA's inhibitory action on the circulating suPAR expression.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 14 Years 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age at entry is between 14 and 70 years
- •biopsy-proven primary FSGS
- •proteinuria >=3 g/day
- •without corticosteroids or CsA treatment before entry
排除标准
- •Chronic Inflammatory Diseases
- •malignant tumor
- •diabetes mellitus
- •contraindications for the treatment of corticosteroids or CsA treatment
- •untolerate to or unwilling to accept corticosteroids or CsA treatment
结局指标
主要结局
serum suPAR level when proteinuria reduction >=50% or complete remission
时间窗: 6 months after steriod alone or CsA plus steriod treatment
serum suPAR level when proteinuria reduction of \>=50% or complete remission occurs within \<=6 months of steroid alone or CsA plus steroid treatment
次要结局
- serum suPAR level after 6 months of steroid or CsA treatment without remission(6 months after steroid alone or CsA plus steroid treatment)
研究者
Wei Shi
Director of renal division of Guangdong General Hospital
Guangdong Provincial People's Hospital
研究点 (1)
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