A clinical study of Amrutadi vati and Vasadi vati in the management of Tamaka shwasa w.s.r. to Bronchial asthma
试验速览
- 阶段
- 1/2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Change in the clinical symptoms of Bronchial Asthma like
研究概览
简要总结
Ayurveda refers to Bronchial Asthma as Tamaka shwasa. Asthma is a chronic inflammatory disorder of the airways. In which the chronic inflammation causes an associated increase in airway hyper responsiveness that leads to recurrent episodes of wheezing, breathlessness, chest tightness and coughing, particularly at night or in the early morning.
In modern medicine management of Asthma is done by Bronchodilators and corticosteroids controlling it but leading to dependency on allopathic drugs increasing its severity along with other side effects also.With the help of Ayueveda if we can control attacks of Shwasa and decrease dose of other medicine it will be very useful to society.
According to Acharya Charaka the medicaments, foods and drink which control both Vayu and Kapha and having Ushna and Vatanulomana property should be given in Tamaka shwasa. Therefore Amrutadi vati was taken from Chakradatta Hikka Shwasa chikitsa prakranam which contains Guduchi, Nagarmotha, Bharangi, Kantakari, Tulsi, Pippali. This yoga has kapha, vatashamaka property by katu, tikta rasa and ushna virya. Vasadi vati was taken from Yogratnakar shwasa chikitsa adhyay, which contains Vasa, Haridra, Dhanyak, Guduchi, Bharangi, Pippali, Sunthi, Kantakari, Marich. This yoga has kaphashamaka property by katu tikta rasa and vatashamaka property by ushna virya.
Dose of both the drugs were 2tab. 500mg each tds after food with luke warm water for 8weeks and follow up was for 4weeks.
Total 75 patients were registered among them in Group A Amrutadi vati group total 41 patients were registered out of which 36 patients completed the treatment and 05 discontinued. In Group B Vasadi vati group total 34 patients were registered out of which 31 were completed the treatment and 03 discontinued.
Maximum 30.67% patients were belonged to the age group of 41 to 50 years, 61.33% were male, 38.67% were house wives, 13.33% were expose to dust, 48% were having constipation, 64% were having no addiction, 45.33% had past history of allergy, 68% were taking inhaler as modern medicine, 42.67% had positive family history of asthma.
In chief complaints Dyspnoea was found in 100% patients, Cold in 64% patients, productive coughing in 46.67% patients and dry coughing was found in 16% patients.
Maximum 60% patients were suffering from asthmatic attack on exertion and 52% during night time, 1to 5year chronicity was found in 38.67% patients. In relieving factors Orthopnoea was found in 81.33% patients.
In Group A highly significant results were found in Dyspnoea, reducing the frequency of Dyspnoea, reduction of duration of Dyspnoea, decreasing the dose of emergency medicine used per week, Productive coughing and cold. In Group B highly significant results were found in Dyspnoea, reducing the frequency of Dyspnoea, reduction of duration of Dyspnoea, decreasing the dose of emergency medicine used per week, productive coughing and cold.
Group A showed significant improvement in S.Cholesterol and Total Protein. Group B showed significant improvement in FEV1%.
Group A provided marked improvement followed by moderate improvement in maximum patients while Group B provided moderate improvement followed by marked improvement in maximum patients.
It can be concluded from the study that this work can be helpful in management of Tamaka shwasa Bronchial asthma.
No any adverse effect was found in both the trial drugs but further Amrutadi vati proved as more effective in the patient of Bronchial Asthma in compare to Vasadi vati.
研究设计
- 研究类型
- Interventional
- 分配方式
- Not Applicable
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 16.00 Year(s) 至 70.00 Year(s)(—)
- 性别
- All
入选标准
- •Patients of either sex aged between 16 to 70 years Patients having signs and symptoms of Tamak shwasa described in ayurvedic texts and modern texts will be included.
排除标准
- •Patients of age less than 16 and above 70 years Patients with status asthmaticus asthma due to cardiac origin Patients having complications like cor pulmonale emphysema pneumonia tuberculosis and malignancy etc and breathlessness due to diabetes mellitus severe anaemia renal failure major endocrine disorders will be excluded from the study.
结局指标
主要结局
Change in the clinical symptoms of Bronchial Asthma like
时间窗: 8 weeks study and 4 weeks follow up
Dyspnoea
时间窗: 8 weeks study and 4 weeks follow up
Wheezing
时间窗: 8 weeks study and 4 weeks follow up
Coughing
时间窗: 8 weeks study and 4 weeks follow up
Chest tightness etc
时间窗: 8 weeks study and 4 weeks follow up
次要结局
- Change in Spirometry(8 weeks study and 4 weeks follow up)
