Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion Following Catheter Ablation of Atrial Fibrillation
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- recurrence of atrial arrhythimia
研究概览
简要总结
The effects colchicine administration for acute pericardial effusion after radiofrequency catheter ablation (RFCA) of atrial fibrillation on the recurrences of arrhythmia.
详细描述
RFCA was started as a rhythm control of atrial fibrillation about 10 years before and the superiority of RFCA to medical treatment has been continuously reporting, so RFCA is globally performed nowadays. Acute pericardial effusion could occur during RFCA as complication, that might be developed to cardiac tamponade needed immediate pericardiocentesis. The inflammation developed after pericardiocentesis might be associated with the recurrences of atrial fibrillation, it could be presumed by the frequent occurrence of atrial fibrillation after open-heart surgery. The inflammation can be suppressed by administration of colchicine and the effects of colchicine have been proven to decrease the development of atrial fibrillation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients needed to pericardiocentesis during RFCA for paroxysmal or persistent atrial fibrillation.
排除标准
- •Hypersensitivity on Colchicine
- •The existence of intra-cardiac thrombus on trans-esophageal echocardiography
- •Pregnancy
研究组 & 干预措施
Colchicine
Impact of Colchicine therapy on arrhythmia Recurrence after Acute Pericardial Effusion following Catheter Ablation of Atrial Fibrillation
干预措施: Colchicine (Drug)
结局指标
主要结局
recurrence of atrial arrhythimia
时间窗: 1 year after colchicines administration
Assessment of the recurrence of atrial arrhythimia 1 year after colchicines administration
次要结局
- recurrence of atrial arrhythimia(3 year after colchicines administration)
研究者
Yong Seog Oh
MD
Seoul St. Mary's Hospital