Randomized controlled clinical study to evaluate the efficacy of Pushkarmuladi kwath as an adjuvant therapy in vataj hridrog with special reference to stable angina

Hridroga (Heart disease) is very common in present scenario due to the sedentary life style and increase psychosocial stress. The major causative factors i for heart problems are cigarette smoking, tobacco chewing, alcohol consumption, junk foods and obesity. According to WHO Ischemic heart disease or Coronary artery disease is the major causes of mortality. Therefore, it is needed to explore knowledge of heart disease time to time. The main purpose of this reserch is to promote the awareness about the heart disease, so prevalence of such problem can be reduced. Hridroga is among those diseases mentioned in Ayurveda where in the description is quite brief and the Ayurvedic view point needs clarification. In view of the increasing evidence of cardiac disorders in the present times this aspect assumes added importance.

Among the five types of Hridroga described, in Vatika variety Ayurveda seems to have conceived the disease entity that comes under Angina. Stable angina is effectively managed in  modern medicine with the aim of relief in pain, normalization of ECG changes, and improvement in exercise tolerance and health related quality of life and overall survival. But still many patients are left untreated or improperly treated due to drug tolerance, serious adverse effects, un affordable cost price of the treatment and poor accessibility despite best treatment modalities available. And for a group of refractory angina patient a novel effective drug is required. Therefore, "Randomized controlled clinical study to evaluate the efficacy of Pushkarmuladi kwath as an adjuvant therapy in Vataj Hridrog with special reference to stable Angina" study was undertaken.

In this study 60 patients will be randomly selected showing signs and symptoms of Vataj Hridrog and are randomised into 2 groups. Trial group will be treated with stanandard treatment with Pushkarmaladkwath as an adjuvant therapy while control group will be treated with standard treatment only. In clinical study patients will be examined according to subjective criteria which includes Chest pain (Hridshoola Bheda), Palpitation (Hrid dravah), Sweating, Vertigo (Moha), Fatigue (Shosha), NYHA (New York Heart Association) Score for Angina and objective criteria including ECG (Electrocardiogram) (Before and After treatinent) 2. TMT (Treadmill Machine Exercise Stress Test) (Before and After treatment) 3. Physical haemodynamic tests: (At each follow up) i. Heart Rate (HR) ii Systolic Blood Pressure (SBP) iii. Diastolic Blood Pressure (DBP) 4 Laboratory Blood Chemistry Tests as under: 1. CBC (Complete Blood Count) II. Lipid Profile before treatment and 45 days after treatment. The observations will be drawn after completion of clinical study and conclusion will be drawn accordingly. The study will be published after completion of trial.