Research for the mechanism of drug-drug interaction between Panax notoginseng saponins and aspirin based on the esterase enzyme and Intestinal flora

Beijing University of Chinese Medicine, Dongzhimen hospital0 个研究点开始时间: 待定最近更新: 2023年2月20日

试验速览

暂无简介。

•1. Aged 45-75 years;
•2. meet the diagnostic criteria of CHD;
•3. meet the diagnostic criteria of grade I–II angina according to the Canadian Cardiovascular Society (CCS);
•4. meet the diagnostic criteria of blood stasis;
•5. meet the diagnostic criteria of stable angina pectoris;
•6. take regular aspirin for at least one month;
•7. be informed of the study and voluntarily sign an informed consent.

•1. mental or physical disorders;
•2. pregnant, breast-feeding, and menstruating women, as well as women planning pregnancy within three months;
•3. severe heart disease(acute myocardial infarction or acute myocardial infarction in six months), severe cardiopulmonary dysfunction (e.g. cardiac function II);
•4. severe primary diseases, such as liver and renal hematopoietic system damage, liver function (ALT>=2 ULN, AST>=2 ULN, kidney function, Cr> 1.0 ULN), or nervous and mental disorder;
•5. poorly controlled hypertension (systolic pressure >160 mmHg; or diastolic pressure>100mmHg);
•6. having participated in clinical trials in the last three months;
•7. underwent surgery or had hemorrhagic tendency in the last eight weeks;
•8. drug allergy history or with allergic constitution;
•9. diabetes;
•10. poor compliance or unsuitability for this clinical trial by investigators judgment.

发起方

Beijing University of Chinese Medicine, Dongzhimen hospital