NCT02955407已完成不适用
Genetic Predisposition for Reduced Back Muscle Strength and Back Muscle Endurance in Patients With Chronic Non-specific Low Back Pain
Balgrist University Hospital1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2016年9月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Polymorphism ACE Gene
研究概览
简要总结
Patients with inflammatory back pain were shown to differ from healthy controls in genotype of the Angiotensin-converting enzyme (ACE), which regulates vasoconstriction/-dilatation. The aim of this study is to investigate whether genetic reduction of muscle perfusion might be a pathophysiological pathway of how genes influence chronic non-specific low back pain (LBP).
详细描述
The following genes will be investigated:
- Insertions-/deletions-polymorphism of the angiotensin-converting enzyme (ACE-I/D gene polymorphism; 3 genotypes: ACE-II, ACE-ID, ACE-DD).
- Anti-adhesive extracellular matrix protein Tenascin-C: gene polymorphism rs2104772
The goals of this study are to investigate whether these genotypes correlate with 1) endurance of back muscles, 2) comorbidities such as asthma and diabetes and 3) the risk for LBP as assessed by a LBP-classification tool.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Spinal surgery
- •Spinal fracture
- •Inflammation
- •Severe chronic disease which make intensive physical activity impossible (osteoporosis, cardiovascular heart diseases)
结局指标
主要结局
Polymorphism ACE Gene
时间窗: baseline
Polymorphism Tenascin Gene
时间窗: baseline
次要结局
- Back muscle endurance in Sorensen test(baseline)
研究者
研究点 (1)
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