Influences of Long Term Hormone Therapy on Physical Fitness and Vascular Function in Transgender Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Agility
研究概览
简要总结
Transgender women who transitioned from male to female by hormone therapy demonstrate similar physical fitness and vascular function to males or females.
详细描述
This cross-sectional study was to compare physical fitness and vascular function between cisgender men, cisgender women, and transgender women.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 35 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Cisgender men group (Body mass index between 18.5-24.9 and NO NCDs).
- •Cisgender women group (Body mass index between 18.5-24.9, No pregnant, NO NCDs).
- •Transgender women with orchiectomy (Body mass index between 18.5-24.9, taking estradiol, testosterone level below 10 nmol/L, NO NCDs).
- •Transgender women without orchiectomy (Body mass index between 18.5-24.9, taking estradiol and anti-androgen, testosterone level below 10 nmol/L, NO NCDs).
排除标准
- •Participants had an injury during testing.
结局指标
主要结局
Agility
时间窗: Baseline
Agility will be measured by T-test protocol with timing gate device (SpeedLight Timing System, Swiftperformance).
Height
时间窗: Baseline
Height will be measured with automated body composition machine (ioi 353, Jawon medical).
Bone mineral density
时间窗: Baseline
Bone mineral density will be measured with dual energy x-ray absorptiometry (Prodigy-Pro, GE healthcaare).
T-score of bone density
时间窗: Baseline
T-score will be measured with dual energy x-ray absorptiometry (Prodigy-Pro, GE healthcaare). T-score was separated into 3 categories, 1 or higher of T-score that is the healthy bone, -1 to -2.5 of T-score that is osteopenia, and -2.5 or lower that is osteoporosis.
Flexibility
时间窗: Baseline
Sit and reach test will be measured by sit and reach protocol with sit and reach box (Grandsport).
Body weight
时间窗: Baseline
Body weight and height will be measured with automated body composition machine (ioi 353, Jawon medical).
Heart rate
时间窗: Baseline
Heart rate will be measured with automated blood pressure device (CARESCAPE V100, GE Dinamap).
Blood pressure
时间窗: Baseline
Systolic blood pressure and diastolic blood pressure will be measured with automated blood pressure device (CARESCAPE V100, GE Dinamap). Mean arterial blood pressure was calculated from systolic blood pressure and diastolic blood pressure via mean arterial pressure formula.
Macro vascular function
时间窗: Baseline
Macro vascular function will be measured by brachial artery flow-mediated dilatation protocol on brachial artery with ultrasonography equipment (EPIQ 5G, Phillips).
Arterial stiffness
时间窗: Baseline
Arterial stiffness will be measured with brachial-ankle pulse wave velocity (VP-1000 plus, omrom Healthcare).
Micro vascular function
时间窗: Baseline
Micro vascular function will be measured by post-occlusive hyperemia protocol of fingertip cutaneous blood flow with laser doppler flowmetry device (PeriFlux system 5000, Perimed).
Muscle mass
时间窗: Baseline
Muscle mass will be measured with dual energy x-ray absorptiometry (Prodigy-Pro, GE healthcaare).
Muscular power
时间窗: Baseline
Muscular power will be measured by vertical jump with force plate detected machine (Ballistic Measurement System \& FT 700 Power Cage, Fitness Technology).
Speed
时间窗: Baseline
Speed will be measured by sprint test for 40 meters with timing gate device (SpeedLight Timing System, Swiftperformance).
Resting metabolic rate
时间窗: Baseline
Energy expenditure will be measured by canopy study protocol with stationary gas analyzer (VMAX, Encore 29 system).
Vascular structure
时间窗: Baseline
Intima-Media Thickness will be measured with ultrasonography equipment on carotid artery (EPIQ 5G, Phillips).
Muscle strength and muscle endurance
时间窗: Baseline
Muscle strength and muscle endurance will be measured by concentric/concentric protocol with isokinetic machine (Biodex Multi-Joint System-Pro, Biodex).
Balance
时间窗: Baseline
Balance will be measured by balance error scoring system (BESS) protocol with postural sway detected machine (Biosway, Biodex).
Anaerobic fitness
时间窗: Baseline
Anaerobic fitness will be measured by Wingate test protocol with ergocycle (Monark 894e).
Fat mass
时间窗: Baseline
Fat mass will be measured with dual energy x-ray absorptiometry (Prodigy-Pro, GE healthcaare).
Bone mineral content
时间窗: Baseline
Bone mineral content will be measured with dual energy x-ray absorptiometry (Prodigy-Pro, GE healthcaare).
Cardiorespiratory fitness
时间窗: Baseline
Maximal oxygen consumption will be measured by Bruce protocol for treadmill test with stationary gas analyzer (VMAX, Encore 29 system).
Coordination and reaction time
时间窗: Baseline
Coordination and reaction time will be measured by eye-hand coordination protocol with light reacted device (FITLIGHT Trainer).
次要结局
- Stress level(Baseline)
- Quality of life level(Baseline)
研究者
Prof. Dr.Daroonwan Suksom
Faculty of Sports Science
Chulalongkorn University
