Glutathione Peroxidase Activity in Subjects With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement.
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Level of GPx in blood samples
研究概览
简要总结
The aim of this project is to investigate the association of glutathione peroxidase (GPx) and severe aortic stenosis (AS), as well as the impact of transcatheter aortic valve replacement (TAVR) on GPx activity post-procedure. The burden of oxidative stress will be determined by the measurement of GPx, superoxide dismutase (SOD) and lipoprotein A (Lp(a)). We hypothesize GPx activity is reduced in participants with severe AS vs control groups and GPx activity is to increase after TAVR is performed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age >18 years
- •Patients with severe AS including participants with low flow, low gradient severe AS and paradoxical severe AS
- •Patients meeting criteria for TAVR procedure
排除标准
- •Previous aortic valve replacement (surgical or TAVR)
- •Participants undergoing chemotherapy
- •End stage liver disease/cirrhosis (liver produces GSH)
结局指标
主要结局
Level of GPx in blood samples
时间窗: Baseline up to 6 months
Glutathione peroxidase activity levels measured from whole blood in U/L units in participants with severe aortic stenosis after transcatheter valve replacement compared with the matched population
次要结局
未报告次要终点