Effect of Epidural Morphine and Midazolam on Postoperative Painin Patients Undergoing Major Abdominal Cancer Surgery
试验速览
- 阶段
- 1 期
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- time to first request of analgesia
研究概览
简要总结
this study aim to Compare the effect of preoperative Epidural Midazolam, Morphine and their combination in postoperative pain relief and total morphine consumption.
详细描述
Major abdominal surgeries with abdominal incisions lead to severe abdominal pain, which if treated inadequately, can cause shallow breathing, atelectasis, retention of secretions and lack of cooperation in physiotherapy. This increases the incidence of post-operative morbidity and leads to delayed recovery.Epidural anesthesia is safe and inexpensive technique with the advantage of providing surgical anesthesia and prolonged postoperative pain relief. It also an effective treatment of operative pain blunts autonomic, somatic and endocrine responses. Morphine and midazolam can be used as adjuvant to bupivicain to reduced the postoperative pain
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA I-II patients scheduled for major abdominal cancer surgeries
排除标准
- •patients with known allergy to the study drugs,
- •significant cardiac, respiratory, renal or hepatic disease,
- •drug or alcohol abuse,
- •psychiatric illness that would interfere with perception and assessment of pain.
研究组 & 干预措施
MI
Bupivacaine 0.25% + midazolam 5mg in total volume 10m1
干预措施: midazolam (Drug)
MM
Bupivacaine 0.25% + midazolam 5mg and morphine 5mg in total volume 10ml
干预措施: midazolam (Drug)
MO
bupivacaine 0.25% + morphine 5 mg in total volume 10 ml
干预措施: midazolam (Drug)
结局指标
主要结局
time to first request of analgesia
时间窗: 1st 48 hours postoperative
the time between the end of operation and tracheal extubation to the first request for supplemental analgesics and its administration to the patient
次要结局
- the cumulative consumption of morphine in the 1st 48h postoperatively(1st 48 hours postoperative)
研究者
Shereen Mamdouh
associate professor of anesthesia, ICU and pain manegement
Assiut University