The Effect of Esmolol on Pain Due to Rocuronium Injection Pain
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- The injection pain due to rocuronium
研究概览
简要总结
90 American society of anesthesiology (ASA) physical status I and II patients undergoing general anesthesia for elective surgery will be included in the study. Patients will be randomized into three groups. Group E will receive esmolol (1 mg/kg), Group IL lidocaine (0.5 mg/kg)and Group C placebo(NaCl 0.9%, 5 mL), followed by a 0.05 mg/kg rocuronium. After intravenous induction with propofol, adequate muscle relaxation for intubation will be received by 0.5 mg/kg rocuronium.
详细描述
Patients will be observed after injection of rocuronium 0.05mg/kg, then immediately asked if they have pain in the arm. The response are assessed; discomfort, pain, and withdrawal of the hand are recorded and graded using a 4-point scale (none, mild, moderate, or severe). After the intubating dose of rocuronium, withdrawal reactions are scored as follows: (a) no pain response, (b)pain limited to the wrist, (c) pain limited to the elbow/shoulder, or (d) generalized pain response.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ASA physical status I and II patients
- •Undergoing general anesthesia for elective surgery
排除标准
- •Known allergy to esmolol or lidocaine
- •Chronic pain
- •Pregnancy
- •Withdrawal of consent by the patient
研究组 & 干预措施
brevibloc (esmolol)
Group E will receive esmolol (1 mg/kg), Group L lidocaine (0.5 mg/kg)and Group C placebo(NaCl 0.9%, 5 mL)
干预措施: Esmolol (Drug)
brevibloc (esmolol)
Group E will receive esmolol (1 mg/kg), Group L lidocaine (0.5 mg/kg)and Group C placebo(NaCl 0.9%, 5 mL)
干预措施: rocuronium (Drug)
Aritmal (Lidocaine)
Group E: esmolol (1 mg/kg) Group L: lidocaine (0.5 mg/kg) Group C: placebo(NaCl 0.9%, 5 mL)
干预措施: Lidocaine (Drug)
Aritmal (Lidocaine)
Group E: esmolol (1 mg/kg) Group L: lidocaine (0.5 mg/kg) Group C: placebo(NaCl 0.9%, 5 mL)
干预措施: rocuronium (Drug)
Placebo (NaCl 0.9%, 5 ml)
Group E: esmolol (1 mg/kg) Group L: lidocaine (0.5 mg/kg) Group C: placebo(NaCl 0.9%, 5 mL)
干预措施: rocuronium (Drug)
Placebo (NaCl 0.9%, 5 ml)
Group E: esmolol (1 mg/kg) Group L: lidocaine (0.5 mg/kg) Group C: placebo(NaCl 0.9%, 5 mL)
干预措施: Placebo (Drug)
结局指标
主要结局
The injection pain due to rocuronium
时间窗: 1 month
Pain will be recorded and graded using a 4-point scale (none, mild, moderate, or severe).
次要结局
- Score on pain due to injection of rocuronium(1 month)
研究者
Fatma Kavak Akelma
Specialist
Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital