NCT00449566Unknown不适用
Magnetic Resonance Imaging of Brain Development in Autism
适应症
试验速览
- 阶段
- 不适用
- 发起方
- UMC Utrecht
- 入组人数
- 300
- 试验地点
- 1
研究概览
简要总结
The purpose of this study is to investigate brain development in autism by longitudinally assessing children with autism, as well as typically developing controls, using advanced MR techniques. We will use longitudinal diffusion tensor imaging (DTI) measures to investigate the protracted development of long-range white matter fibers in autism. In addition, we will investigate the effect of autism risk genes on brain development.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged 6 - 18 years at initial MRI
- •Inclusion criteria for subjects with autism
- •DSM-IV (APA, 1994) diagnosis of autism, according to ADI-R interview
- •Inclusion criteria for controls
- •no DSM-IV (APA, 1994) diagnosis, according to DISC interview
- •no scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)
排除标准
- •major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system
- •presence of metal objects in or around the body (pacemaker, dental braces)
- •history of or present neurological disorder
- •for individuals over 12 years of age: legal incompetence, defined as the obvious inability to comprehend the information that is presented by the investigator and is outlined in the Information letter and on which the decision to participate in the study is to be based
研究者
研究点 (1)
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