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临床试验/NCT04128735
NCT04128735已完成不适用

The Prevalence of Diastolic Dysfunction in Morbidly Obese Patients Undergo Bariatric Surgery

Mahidol University1 个研究点 分布在 1 个国家目标入组 116 人开始时间: 2019年10月30日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
116
试验地点
1
主要终点
Prevalence of diastolic dysfunction

研究概览

简要总结

Morbidly obese patients are at risk for diastolic cardiac dysfunction, which can lead to adverse event, such as, diastolic heart failure postoperatively. Preoperative screening by transthoracic echocardiogram is difficult due to anatomical challenge, therefore the prevalence of this problem may be underestimated. The investigator would like to perform transesophageal echocardiogram in this group of patients after anesthesia induction to demonstrate the true prevalence of this syndrome.

详细描述

Morbidly obese patients are at risk for both respiratory and cardiovascular abnormalities. Many cardiac problems were previously reported including left ventricular hypertrophy, right and left ventricular systolic dysfunction etc. Diastolic cardiac dysfunction can be found in normal left ventricular systolic function and can lead to diastolic heart failure postoperatively.

Preoperative screening by transthoracic echocardiogram is difficult due to anatomical challenge (thick chest wall, narrowing of inter-rib space), therefore the prevalence of this problem may be underestimated. Transesophageal echocardiogram provides better cardiac view, but requires sedation during procedure. So, it is not practical for out-patient setting. The investigator would like to perform transesophageal echocardiogram in this group of patients after anesthesia induction to demonstrate the true prevalence of this syndrome.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Every patient scheduled for bariatric surgery in Siriraj hospital

排除标准

  • Patient refusal
  • patient with contraindication for transesophageal echocardiogram such as preexisting esophageal disease, recent upper gastrointestinal bleeding, coagulopathy, etc. (according to American society of Echocardiography guideline)

结局指标

主要结局

Prevalence of diastolic dysfunction

时间窗: during surgery

Prevalence of diastolic dysfunction according to American society of echocardiography definition

次要结局

  • Length of hospital stay(up to 5 days)
  • Prevalence of other cardiac abnormalities(during surgery)
  • Incidence of pulmonary adverse events(within 24 hours after surgery)
  • Incidence of cardiac adverse events(within 24 hours after surgery)
  • Incidence of oral and airway trauma(within 24 hours after surgery)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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