Evaluation of the Impact of Rutin and Vitamin C Combination on Oxidative Stress, Insulin Sensitivity and Lipid Profile in Type 2 Diabetic Patients
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 53
- 试验地点
- 1
- 主要终点
- Oxidative stress marker (MDA) and antioxidant capacity (SOD) in diabetic patients
研究概览
简要总结
The objective of this study is to investigate the effect ofRutin and Vitamin C combination in comparison with vitamin C alone on the oxidative and antioxidative status , insulin resistance and lipid profile in type 2 diabetic patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •• Patients' age 35 years or older having type 2 diabetes mellitus.
- •Patients taking oral diabetic medications (Sulfonylurea) not taking Insulin.
- •Able to understand and willing to sign a written informed consent document
排除标准
- •• Pregnant and breast feeding females
- •use of vitamin supplements containing vitamin C or other antioxidants.
- •patients with renal or hepatic failure.
- •patients taking insulin as antidiabetic treatment
研究组 & 干预措施
Control group
patients will receive their usual antidiabetic treatment only for 8 weeks.
Rutin C group
patients will receive Rutin 60 mg in combination with vitamin C 160 mg three times daily in addition to usual antidiabetic treatment for 8 weeks..
干预措施: Rutin in combination with Vitamin C (Dietary Supplement)
Vitamin C group
patients will receive vitamin C 500 mg once daily in addition to usual antidiabetic treatment for 8 weeks.
干预措施: Vitamin C (Dietary Supplement)
结局指标
主要结局
Oxidative stress marker (MDA) and antioxidant capacity (SOD) in diabetic patients
时间窗: Two months
Effect of Rutin and vitamin C combination or vitamin C alone on oxidative stress marker (MDA) and on antioxidant capacity (SOD) in diabetic patients after 8 weeks of treatment.
Insulin resistance in diabetic patients .
时间窗: Two months
Effect of Rutin and vitamin C combination or vitamin C alone on insulin resistance in diabetic patients before i and after treatment for 8 weeks .
Lipid profile in diabetic patients (TC,TG,HDL-c,LDL-c).
时间窗: Two months
Impact of Rutin and vitamin C combination or vitamin C alone on lipid profile in diabetic patients (TC,TG,HDL-c,LDL-c).
次要结局
- Quality of life of diabetic patients and this will be evaluated by using Quality of Life Questionnaire (Short Form 36 questions (SF-36)) .(Two months)
研究者
sara ramzy ragheb
Assistant Lecturer
Ain Shams University