NCT00615628终止不适用
Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18: Examination of Osteosarcoma Tissue Samples From Two Family Members for Loss of Heterozygosity in the Chromosome 18 Region, Genetically Linked With Paget's Disease of Bone
State University of New York - Upstate Medical University1 个研究点 分布在 1 个国家目标入组 8 人开始时间: 2002年4月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- Loss of heterozygosity
研究概览
简要总结
Researchers have previously demonstrated loss of heterozygosity in a region on chromosome 18q, associated with osteogenic sarcomas in bone affected by Paget's disease. The loci used in this study are specifically described by those authors as showing loss of heterozygosity in 6 of 7 affected families.
详细描述
As above, no additional information
研究设计
- 研究类型
- Observational
- 观察模型
- Family Based
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •This is a familial study therefore the only inclusion/exclusion criteria would be that subjects must be a blood relative and over the age of
- •The subjects are proband and father along with unaffected blood relatives. Their peripheral blood will act as a control and provide information to delineate the inheritance from the father, as seen in the son.
排除标准
- •Not part of the family
结局指标
主要结局
Loss of heterozygosity
时间窗: January, 2000 through February 2009
A loss of heterozygosity of a proposed tumor suppressor gene on chromosome 18
次要结局
未报告次要终点
研究者
Timothy Damron, M.D.
Associate Professor
State University of New York - Upstate Medical University
研究点 (1)
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