NCT03953859已完成不适用
Investigation of Cellular DNA Repair Capacity in Human Preimplantation Embryos
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 6
- 试验地点
- 1
- 主要终点
- repair of double strand break in DNA
研究概览
简要总结
The mail aim of the present study is to use molecular methods to analyze the ability of human preimplantation embryos to repair their DNA
详细描述
The main aim of the present study is to investigate the DNA repair pathways of preimplantation embryos, examining the events that take place following induction of a DSB at a unique targeted site. The investigators aim to address questions concerning the functionality of the DNA repair mechanism(s) in developing embryos, before and after genome activation.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 42 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •gamete donors: be at least 21 years of age, in good health and eligible to donate their games through the standard gamete donation programs
- •IVF couples: any couples proceeding with a routine IVF cycle
排除标准
- •less than 21 years of age
- •inability to provide informed consent
结局指标
主要结局
repair of double strand break in DNA
时间窗: up to 12 days
targeted deep sequencing to identify the presence of the double strand break in the DNA and subsequent repair ability of the embryo
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
The Genetic and the Functional Study of DNA Repair System and the Susceptibility to Rheumatoid ArthritisRheumatoid ArthritisNCT01285336China Medical University Hospital
已完成
不适用
A Proof of Concept Study for the DNA Repair Driven by the Mesenchymal Stem Cells in Critical COVID-19 PatientsCOVID-19 PneumoniaNCT04898088SBÜ Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi30
招募中
不适用
Assessment of DNA damage-repair capacity in systemic lupus erythematosus patients as a potential biomarker of response to cyclophosphamide.Lupus nephritisACTRN12620001287921niversity of Auckland17
已完成
不适用
DNA Repair and Genetic Susceptibility to Lung CancerSingle Primary Lung CancerSecond Primary Lung CancerLung CancerNCT00611598Memorial Sloan Kettering Cancer Center218
暂停
不适用
Pilot Study of Biomarkers for Radiation TherapyCancerNCT01050725Benaroya Research Institute100