Clinical study to evaluate anti-inflammatory effects of intravenous azithromycin add-on therapy for the treatment of bacterial pneumonia. - Clinical study to evaluate anti-inflammatory effects of intravenous azithromycin add-on therapy (YCRG0008)

Yokohama City University Medical Center0 个研究点目标入组 80 人开始时间: 2012年5月23日最近更新: 2023年10月17日

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•(1) Patients with hypersensitivity to azithromycin, macrolide or ketolide antibiotic agents (2) Patients with hypersensitivity to levofloxacin or ofloxacin (3) Patients with liver dysfunction (AST, ALT, and total bilirubin > 3 times upper limit of normal range) (4) Patients with severe renal dysfunction (creatinine clearance <30 mL/min) (5) Patients with prior or current evidence of severe heart diseases (NYHA grade IV), congenital or sporadic prolongation of the QT interval, or receiving medications known to cause prolongation of the QT interval (6) Patients with severe underlying diseases or complications that have the difficulties of the evaluations of drug efficacy (7) Patients who require other systemic antibiotic treatments (8)Patients by whom other antimicrobial drugs (internal use or injection) were prescribed for the patient exceeding 48 hours to this infection before investigational new drug trial drug medication (9)Patients with gastrointestinal disorders disrupting drug absorption (10)Pregnant women or females with childbearing potential (11) Any other condition which, in the opinion of the investigator, would make the subject unsuitable for enrollment

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