How Does Cerebellar tDCS Alter Intracortical Inhibition Over Time?
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 3
- 试验地点
- 2
- 主要终点
- Short-interval Intracortical Inhibition (SICI).
研究概览
简要总结
Combining cortical tDCS with behavioral interventions has been shown to have beneficial outcomes in individuals post-stroke. However, cerebellar tDCS is a fairly new approach for individuals with unilateral cortical stroke and there has not been reports of duration of effect of tDCS applied to the cerebellum in this population.
Information gained from this study will serve to fill knowledge gaps on the duration of effect of cerebellar tDCS and the effects of polarity.
The purpose of this study is to determine the duration of effect of ventro-lateral cerebellar transcranial direct current stimulation (tDCS) in healthy adults through cortical excitability (CE), cognitive, language and motor assessment measures. Primary aim: Compare baseline CE from left motor cortex of first dorsal interosseous (FDI) and orbicularis oris (OO) areas to CE post cerebellar tDCS at 15 minutes, 45 minutes and 75 minutes. Single-pulse and paired-pulse transcranial magnetic stimulation (TMS) will be used to measure and compare stimulus response curve (S/R curve), cortical silent period (CSP) and short-interval intracortical inhibition (SICI) in the hand area and facial area of the left primary motor cortex at each time point.
Secondary aim: Compare baseline performance on cognition, motor learning and language tasks to performance at 15, 45 and 75 minutes after receiving tDCS. Digit Symbol Substitution Test (DSST), Serial Reaction Time Test (SRTT) and Lexical Decision tasks will be presented via a computer interface.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Eligible participants must be over the age of 18 years of age
- •must be fluent in English
- •have adequate vision to see a computer screen from 12-18 inches, fine motor skills to press a key on a computer keyboard and hearing to hear directions and questions provided by the researcher
- •Individuals must also be able to read words and phrases
排除标准
- •Pregnancy
- •history of seizures
- •neurologic injury including concussion/head injury or stroke or other neurologic conditions
- •History of documented learning disabilities and/or ADHD
- •Metal implants in the body (excluding dental fillings), psoriasis or eczema affecting the scalp.
结局指标
主要结局
Short-interval Intracortical Inhibition (SICI).
时间窗: baseline, 15,45 and 75 minutes post-tDCS
Change in MEP as reflected in EMG from 1) hand (FDI muscle) and 2) mouth (orbicularis oris muscle). following a subthreshold conditioning pulse followed by a suprathreshold test pulse
stimulus/response curve (S/R Curve)
时间窗: baseline, 15,45 and 75 minutes post-tDCS
change of motor evoked potential (MEP) as reflected in EMG from 1) hand (FDI muscle) and 2) mouth (orbicularis oris muscle).following single pulse transcranial magnetic stimulation (TMS) to the primary motor cortex of varying intensities.
Cortical Silent Period (CSP)
时间窗: baseline, 15,45 and 75 minutes post-tDCS
Change in silent period of a contracted muscle shown through EMG from 1) hand (FDI muscle) and 2) mouth (orbicularis oris muscle). following a single supra-threshold stimulus pulse to the primary motor cortex using TMS.
次要结局
- Serial Reaction Time Test (SRTT)(baseline, 15, 45 and 75 minutes post stimulation)
- Digit Symbol Substitution Test (DSST)(baseline, 15, 45 and 75 minutes post stimulation)
- Lexical Decision Task(baseline, 15, 45 and 75 minutes post stimulation)