Association Between Administration of Dexmedetomidine and Postoperative Mortality in Hospitals Among Inpatients Undergoing Surgeries Under General Anaesthesia Using Propofol
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 518,043
- 主要终点
- in-hospital all-cause mortality
研究概览
简要总结
The present multicentre retrospective cohort study aimed to investigate the association between intraoperative administration of dexmedetomidine and postoperative mortality in hospitals.
The investigators set out to test the hypothesis that perioperative dexmedetomidine use, as an adjunct to general anesthesia, diminishes postoperative mortality in hospitals across all categories of surgical patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult patients (aged ≥18 years)
- •undergo general anaesthesia with propofol
- •from January 1, 2014 to June 30, 2018
排除标准
- •patients undergoing intervention procedures under monitored anaesthesia care (MAC)
- •patients undergoing minor procedures under local or regional anaesthesia
研究组 & 干预措施
dexmedetomidine
dexmedetomidine group: abbreviated for dexmedetomidine group, refers to the group with intraoperative administration of dexmedetomidine adjunct to propofol
干预措施: Dexmedetomidine (Drug)
结局指标
主要结局
in-hospital all-cause mortality
时间窗: from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year
in-hospital deaths or discharged to hospice (or home)
次要结局
- admission to the intensive care unit (ICU)(from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year)
- length of postoperative hospital stay(from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year)
- adverse events after surgery(from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year)
研究者
Chong Lei, MD & phD
Principal Investigator
Xijing Hospital