Feasibility Study of PET-MRI as a Platform for Image Guidance and Adaptive Radiation Therapy in Patients With Esophagogastric Cancer
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Feasibility of PET-MRI to visualize and assess impact of RT treatments on esophagogastric tumors
研究概览
简要总结
This is a single arm, single centre, investigator initiated study to investigate the feasibility of using PET-MRI imaging in radiation treatment workflow in up to 15 patients with esophagogastric cancer. PET-MRI imaging will be completed before the start of radiation treatment. MRI imaging will be completed during radiation treatment and after radiation treatment. These images will not be used to plan the radiation treatment and routine clinical care will be provided.
The goal of this study is to gather information that will allow the radiation team to include MRI and PET imaging into the radiation treatment workflow for patients with esophageal cancer receiving radiation therapy in the future.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients 18 years or older
- •Diagnosed with locally advanced esophageal cancer being considered for conventional RT >4 weeks
- •Ability and willingness to provide written informed consent
排除标准
- •Contraindication for MRI
- •Contraindication for Gadolinium (i.e. inability to lie supine for at least 60 minutes)
- •Any patient who is pregnant or breastfeeding
- •Pacemaker or implanted defibrillator
- •Claustrophobia
研究组 & 干预措施
PET-MRI
PET-MRI in esophagogastric cancers
干预措施: PET-MRI (Procedure)
结局指标
主要结局
Feasibility of PET-MRI to visualize and assess impact of RT treatments on esophagogastric tumors
时间窗: 2 years
Detection of metastases on DWI and gadolinium enhanced T1-weighted 3D VIBE sequences.
次要结局
- Difference in manual GTV segmentation using PET-MRI(2 years)
- Quantification of dosimetric advantages of PET-MRI treatment plan(2 years)