CTRI/2020/02/023402招募中4 期
Gemcitabine and Carboplatin versus Gemcitabine and Paclitaxel Chemotherapy in Cisplatin Ineligible Advanced Stage Urothelial Cancers: A Prospective Randomized Control Study. - CAUR CAP
试验速览
- 阶段
- 4 期
- 状态
- 招募中
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1.Age 18 years and above
- •2.ECOG performance status 0,1,2
- •3.Histologically confirmed advanced urothelial cancer of the urethra, bladder, or upper urinary tracts.
- •4.Radiologically confirmed unresectable or metastatic disease
- •5.Estimated GFR less than 60 mL/min as measured by the Cockcroft-Gault method.
- •6.Left ventricular ejection fraction 40% and above
- •7.Chemotherapy naïve patients
排除标准
- •1.Brain metastasis
- •2.End-stage kidney disease requiring haemodialysis
- •3.New York Heart Association(NYHA)grade III or IV 4.Congestive heart failure, or history of unstable angina/ myocardial infarction within six months prior to study entry
- •5.Grade 2 or worse peripheral neuropathy
- •6.Serum SGOT/SGPT levels >5 times the upper normal limits (UNL) provided, Serum Bilirubin (Total) >3 times the UNL.
- •7.Any acquired immunodeficiency state
- •8.Presence of second malignancy
- •9.Pregnant or Lactating females.
研究者
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