NCT00473980已完成4 期
Preoperative Treatment With NSAID in Colorectal Cancer Patients in Relationship to Tumor Host Reactions
Göteborg University1 个研究点 分布在 1 个国家目标入组 28 人开始时间: 1998年12月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Immune reactivity
研究概览
简要总结
The study is designed to evaluate effects of NSAIDs on immune activity inside and close to tumor tissue in patients with colorectal cancer.
详细描述
Study and control patients are randomized to receive preoperative treatment with indomethacin or celecoxib compared to sham treatment.Tumor biopsies are taken at operation and used for analyses of tumor immunity and gene expression.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Colon carcinoma scheduled for curative operation
排除标准
- •Diabetes, steroid medication, liver and kidney impairment
研究组 & 干预措施
Drug
Experimental
Treatment with indomethacin or celecoxib
干预措施: Indomethacin, celecoxib, esomeprazole (Drug)
SHAM
Sham Comparator
Sham treatment
干预措施: Indomethacin, celecoxib, esomeprazole (Drug)
结局指标
主要结局
Immune reactivity
时间窗: Acute evaluations
次要结局
未报告次要终点
研究者
研究点 (1)
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