Investigation of the Suburothelial Myofibroblast Network and of Smooth Muscle Function and Control in the Continent and Incontinent Human Urinary Outflow Tract

Ludwig-Maximilians - University of Munich1 个研究点分布在 1 个国家目标入组 200 人开始时间: 2010年1月最近更新: 2012年3月5日

适应症

试验速览

阶段: 不适用
发起方: Ludwig-Maximilians - University of Munich
入组人数: 200
试验地点: 1

研究概览研究设计入排标准研究者研究点记录与标识符相似试验

研究概览

简要总结

The aim is to find out if adreno-muscarinic synergy is present also in human tissues of the urinary outflow tract that have a dual adrenergic-muscarinic receptor fitting. To further characterise morphology and function of the suburothelial myofibroblast network in the human bladder outlet.

研究设计

研究类型: Observational
时间视角: Prospective

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 是

入选标准

•Tissue will be collected from the operation theatre only after having obtained the patient´s consent and in strictest accordance with histopathological requirements, i.e. after assessment of resection margins. It might be necessary to retrieve the tissue from the pathologist after first pathological assessment is completed. Tissue will be placed in Tyrode´s solution, gassed with 95 % O2 and 5 % CO2, for functional and RT-PCR or Western blot experiments, or in OCT (optimal cutting temperature) compound, snap-frozen in liquid nitrogen, and stored in a -80°C freezer until cutting for immunohistochemical experiments.

排除标准

未提供

研究者

发起方

Ludwig-Maximilians - University of Munich

申办方类型

Other

责任方

Principal Investigator

主要研究者

Alexander Roosen

PD Dr A Roosen

Ludwig-Maximilians - University of Munich

研究点 (1)

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