Child Development and Genetic Biomarkers
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 446
- 试验地点
- 1
- 主要终点
- Scores of cognitive function 1
研究概览
简要总结
A study of the relation between genetic biomarkers and child development in Taiwan.
详细描述
The interaction between gene and environment (G×E) can be a very complicated process that influences child development. As a pilot study of child development biomarkers, this study investigates genes related to child development.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Year 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Scores of cognitive function 1
时间窗: baseline
Bayley Scales of Infant and Toddler Development (Scores from 0 to 140, higher scores mean a better outcome.)
Scores of cognitive function (2 y/o to 6 y/o)
时间窗: baseline
Wechsler Preschool and Primary Scale of Intelligence (Scores from 0 to 200, higher scores mean a better outcome.)
Scores of cognitive psychological function
时间窗: baseline
Cantab MOT, PAL, SWM, SOC tests
Scores of motor ability 2
时间窗: baseline
Measure of Grip and Grasp (Higher scores mean a better outcome.)
Gene test (WES3)
时间窗: baseline
Whole-Exome Sequencing (Use Picard to screen out the variant discovery and genotyping.)
Gene test (WES4)
时间窗: baseline
Whole-Exome Sequencing (Use Genome Analysis Toolkit (GATK) to screen out the variant discovery and genotyping.)
Scores of cognitive function (6 y/o to 16 y/o)
时间窗: baseline
Wechsler Intelligence Scale for Children (Scores from 0 to 200, higher scores mean a better outcome.)
Scores of social behavior 2
时间窗: baseline
Swanson, Nolan, and Pelham, Version IV (Lower scores mean a better outcome.)
Scores of motor ability 1
时间窗: baseline
The Berry-Buktenica Developmental Test of Visual-Motor Integration (Scores from 0 to 81, Higher scores mean a better outcome.)
Gene test (WES2)
时间窗: baseline
Whole-Exome Sequencing (Use Samtools86 to screen out the variant discovery and genotyping.)
Scores of cognitive function 3
时间窗: baseline
Test of Nonverbal Intelligence-Fourth Edition (Scores from 0 to 60, higher scores mean a better outcome.)
Gene test (WES1)
时间窗: baseline
Whole-Exome Sequencing (Use Burrows-Wheeler Aligner (BWA) 85 to screen out the variant discovery and genotyping.)
Scores of language function 2
时间窗: baseline
Preschool Language Impaired Scale(PLS)/Language Impaired Scale(LS) (PLS: Scores from 0 to 65, higher scores mean a better outcome. LS: Scores from 0 to 73, higher scores mean a better outcome.)
Scores of social behavior 1
时间窗: baseline
Clancy Behavior Scale (Scores from 0 to 42, lower scores mean a better outcome.)
Scores of language function
时间窗: baseline
Peabody Picture Vocabulary Test-Revised (Scores from 0 to 124, higher scores mean a better outcome.)
Scores of general development
时间窗: baseline
Comprehensive Developmental Inventory for Infants and Toddlers (Higher scores mean a better outcome.)
Gene test (Mircoarray)
时间窗: baseline
Microarray (Use Axiom Genome-Wide TWB 2.0 Array Plate (TWB 2.0) to analyze SNPs of disease-related biomarkers.)
次要结局
- Scores of quality of life(baseline)
- Scores of participation(2-5 y/o)(baseline)
- Scores of participation(>6 y/o)(baseline)
- Scores of activities(baseline)