Interest of a Systematic One-year Monitoring by 18F-FDG PET-CT of Patients in Complete Remission of Malignant Lymphoma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 主要终点
- role of FDG-PET/CT surveillance at 12months of lymphoma in asymptomatic patient in first complete remission
研究概览
简要总结
In the study, we aimed to characterize the role of FDG PET/CT surveillance at 12 months of malignant lymphoma in asymptomatic patients after a first complete remission and to define a rational follow-up strategy.
详细描述
Most aggressive lymphomas are sensitive to first-line immunochemotherapy and are in first Complete Remission (CR) with initial therapy. CR significantly decreases the risk of recurrence and increases survival. However, a cure is not guaranteed and approximately one third of lymphoma patients have a relapse disease.
FDG PET/CT is a valuable noninvasive tool in the evaluation of lymphomas, especially to differentiate viable lymphoma and fibrosis or necrosis in residual mass.
The majority of relapses are diagnosed based on clinical symptoms reported by patients. And the role of FDG PET/CT for routine surveillance of patients after treatment is controversial.
However, many medical centers use routine follow-up FDG PET/CT in addition to physical examination and laboratory analysis to detect subclinical relapse.
Thus, we can imagine a good timing to routine FDG PET/CT when the tumor burden is small in the asymptomatic window.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •first diagnosis of aggressive lymphoma, complete metabolic remission after a first-line of chemotherapy, no relapse in the first year after the end of treatment
排除标准
- •minor patient, pregnant woman, legal protection (legal curatorship / guardianship), absence of consent
结局指标
主要结局
role of FDG-PET/CT surveillance at 12months of lymphoma in asymptomatic patient in first complete remission
时间窗: one day
detection rate of relapse at 1 year and at the end of follow-up
performances FDG-PET/CT 1 year
时间窗: one day
sensitivity, sensibility, predictive negative value, predictive positive value, accuracy
次要结局
- overall survival and progression-free survival(one day)