NCT01626911Unknown不适用
Continuous Regional Arterial Infusion of Low Molecular Weight Heparin in Patients With Severe Acute Pancreatitis
Nanjing University School of Medicine1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2011年9月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- coagulation related complications
研究概览
简要总结
Our animal studies found that continuous regional arterial infusion (CRAI in the celiac trunk) of low molecular weight heparin (LMWH) could alleviate inflammation, improve global hemodynamics and restore organ function in a porcine model of severe acute pancreatitis (SAP,unpublished).
In this study, the investigators aim to evaluate the effects of CRAI of LMWH in the treatment of SAP patients. The investigators suppose CRAI could help improve the outcomes of these patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Symptoms and signs of severe acute pancreatitis according to Atlanta criteria
- •Within 3 days from the onset of the disease
- •Available for interventional treatment(not sensible to radiocontrast agent)
排除标准
- •Pregnant pancreatitis
- •Receiving surgery or aspiration before;need of early surgery
- •Patients with coagulation disorders
结局指标
主要结局
coagulation related complications
时间窗: 14 days after the placement of celiac trunk catheter
bleeding for the most coagulative parameters
Pancreatic infection
时间窗: 28 days
次要结局
- Hospital duration(Participants will be followed until the date of discharge from the hospital,assessed up to 3 months. Patients who die during hospitalization are excluded from this measurement.)
- Mortality(Participants will be followed until the date of discharge or the date of death from any cause, whichever came first, assessed up to 3 months)
- pancreatic necrosis(28 days)
- ICU duration(Participants will be followed until the date of discharge from the ICU,assessed up to 6 weeks. Patients who die during hospitalization are excluded from this measurement.)
研究者
Weiqin Li
Director of surgical ICU
Nanjing University School of Medicine
研究点 (1)
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