Physical Activity Levels and Statin Therapy: Differences Between Symptomatic and Asymptomatic Statin Users
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 196
- 试验地点
- 1
- 主要终点
- Sedentary time
研究概览
简要总结
Rationale: Combining statin treatment and physical activity is very effective for the prevention of cardiovascular diseases. Statins are well-tolerated by most patients, but may cause statin-associated muscle symptoms (SAMS).
Objective: To identify predictors for SAMS in statin users and to objectively assess physical activity levels and sedentary time between symptomatic and asymptomatic statin users.
详细描述
Combining statin treatment and physical activity is very effective for the prevention of cardiovascular diseases. Statins are well-tolerated by most patients, but may cause statin-associated muscle symptoms (SAMS). Physical activity may exacerbate SAMS, producing decreased physical activity levels or statin nonadherence. However, it is unknown if daily activity patterns differ between symptomatic and asymptomatic statin users.
In this cross-sectional observational study the investigators will assess if physical activity levels and sedentary time differ between symptomatic and asymptomatic statins users. Secondly, questionnaires will be used to assess predictors of SAMS.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Mentally able to give informed consent
- •Statin treatment for at least 3 months
排除标准
- •Known hereditary muscle defect
- •Known mitochondrial disease
- •Other diseases known to cause muscle symptoms (e.g. m. Parkinson or rheumatic diseases)
结局指标
主要结局
Sedentary time
时间窗: during 1 week
Sedentary time (min/day) will be assessed using the activPAL3 micro monitor
Physical activity
时间窗: during 1 week
Physical activity (min/day) will be assessed using the activPAL3 micro monitor
次要结局
- Predictors of statin-associated muscle complaints (SAMS)(1 moment (cross-sectional))