NCT04526223Unknown不适用
Allogeneic HCT Outcomes in MF Patients Exposure to Ruxolitinib During Transplantation
xuna1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2017年4月20日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Time of neutrophils reconstruction
研究概览
简要总结
Increasing experience of Ruxolitinib pre-allo SCT and data concerning Ruxolitinib during transplantation
- Diagnosis MF(includ Post-ET,Post-PV,PMF,MDS/MPN with MF)
- With at least two month Ruxolitinib treatment prior to transplantation
- DAC+BF as myeloablative conditioning regimen
- CSA from day -3 and MMF from day +1 until day 28 ATG Neovii® at dose of 7.5mg/KG for mismatch donor
- received Rux at +6d in ASCT and continued to +60d
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-60 years old, gender is not limited;
- •Diagnosis MF(includ Post-ET,Post-PV,PMF) according to 2016 WHO
- •With at least two month Ruxolitinib treatment before transplantation
- •Informed consent of the patient or his legal representative
排除标准
- •HCT-CI score≥2
- •Woman who is pregnant or nursing
- •MPN Patients who have received allogeneic hematopoietic stem cell transplantation
结局指标
主要结局
Time of neutrophils reconstruction
时间窗: 1 year
Neutrophils count≧0.5G/L without G-CSF
次要结局
- The incidence rate of GVHD(1 year)
研究者
xuna
doctor
Nanfang Hospital, Southern Medical University
研究点 (1)
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