The Different Neural Representation of Self in Depression Patients and Healthy Individuals.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 23
- 主要终点
- Neural representation of self
研究概览
简要总结
To be aware of oneself as a unique entity in the world occurs early in human development and is the prerequisite of normal social functioning. The disturbance of self representation characterizes a variety of mental disorders such as autism and schizophrenia. Negative self-bias was found to serve as the core cognitive mechanism of depression disorder. However, there was no evidence to show the reason lead to negative bias. In the current study, investigators hypothesized that the blurring self representation was the neural correlates in depression disorder.
详细描述
To test investigators' hypothesis, investigators adopted the self-referential task and fMRI to investigate the neural representation of self in depression patients, and compared with healthy control.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients should be clinical diagnosis of major depression disorder.
- •Healthy control participants should be age-matched with depression group, and should have no history of neurological or psychiatric diagnoses
排除标准
- •Patients who also have bipolar disorder, schizophrenia, anxiety disorder
- •Healthy controls who have history of mental disorders
结局指标
主要结局
Neural representation of self
时间窗: through study completion, an average of 2 year
We adopted the self referential task. In the task, participants were asked to judge whether a given word was appropriate to describe oneself (self-judgement condition), a celebrity (other-judgement condition) by pressing one of the two buttons with the index or middle finger. For judgments of each target person (i.e, self and celebrity), there were 3 categories of words describing the mental (personality traits, such as hard-working, friendly), physical (physical attributes, such as black hair, big eyes) and social (social roles, such as student, American) dimension of person knowledge. The fMRI task contained 6 runs, with 4.6 minutes per run. This paradigm and task allowed us to investigated the neural representation of self by comparing the BOLD activity under self-judgement condition with BOLD activity under other-judgement condition.
次要结局
未报告次要终点
研究者
ma, yina
Professor
Beijing Normal University