Impact of Environmental Exposures on Tumor Risk in Subjects at Risk of Hereditary SDHx-related Paragangliomas, Pilot Phase
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 101
- 试验地点
- 1
- 主要终点
- Feasability of the protocol of a national case/control study (PGL.EXPO2)
研究概览
简要总结
The main objective of the pilot phase of PGLEXPO will be to assess the faisability and to precise methodology of a case-control study designed for testing the impact of environmental and professional exposures on the tumoral risk in SDHx-mutation carriers
详细描述
The main objective of the pilot phase of PGLEXPO will be to assess the faisability and to precise methodology of a case-control study designed for testing the impact of environmental and professional exposures on the tumoral risk in SDHx-mutation carriers.
Patients will be selected from subjects with a mutation in one of the SDHx genes. The cases will have developed a tumor, while the controls will be tumor-free. Controls will be matched to the cases according to sex, age and type of gene affected. Past exposures will be sought through a telephone questionnaire.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cases: SDHx mutation carriers diagnosed for a SDHx-related tumor
- •Controls: SDHx mutation carriers with no SDHx-related tumor
排除标准
- •Incapacity to exercise free and informed consent for the study
结局指标
主要结局
Feasability of the protocol of a national case/control study (PGL.EXPO2)
时间窗: 2 years
Successful pairing of 50 cases with 50 controls
次要结局
- Ease of matching cases and controls(2 years)
- Feasibility of matching cases and controls(2 years)