NCT06065306招募中不适用
Potential Diagnostic Biomarkers for Aortic Dissection in the Emergency Department: the Aggrecan, Desmosine, D-dimer-Emergency Department (ADD-ED) Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 47
- 试验地点
- 1
- 主要终点
- Serum levels of D-Dimer, Aggrecan and Desmosine
研究概览
简要总结
The goal of this observational study is to determine the utility of desmosine, D-dimer and aggrecan as early diagnostic biomarkers in aortic dissection. The main questions it aims to answer are:
- To investigate the plasma levels of selected biomarkers in ED patients with confirmed aortic dissection
- To study the diagnostic performance of plasma levels of selected biomarkers for aortic dissection
- To study the association between plasma levels of selected biomarkers and clinical outcomes
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥ 18 years
- •Presentation to the ED with first 24 hours of symptoms suggesting AD, including chest pain, upper back pain, syncope of unknown cause, symptoms of any acute perfusion deficit
- •Confirmed AD
- •the diagnosis of AD adjudicated by an independent expert panel at hospital discharge or death, whichever comes first
- •The expert panel will consist of (1) a specialist in Emergency Medicine and (2) a specialist in Cardiology and (3) a specialist in Cardiothoracic Surgery.
排除标准
- •Age <18 years old
- •Pregnancy
- •Surgery or stenting performed before recruitment
结局指标
主要结局
Serum levels of D-Dimer, Aggrecan and Desmosine
时间窗: Blood samples taken preoperatively
Biomarkers :Serum levels of D-Dimer, Aggrecan and Desmosine will be compared in patients with confirmed AD versus age and sex matched healthy controls
次要结局
未报告次要终点
研究者
Colin Graham
Professor
Chinese University of Hong Kong
研究点 (1)
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