Safety of Rapid Ventricular Pacing During Cerebral Aneurysm Surgery by Multimodal Neuromonitoring
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7
- 试验地点
- 2
- 主要终点
- Cerebral oxygenation during surgery
研究概览
简要总结
To evaluate the effect of rapid ventricular pacing on the oxygenation of the brain in patients scheduled for cerebral aneurysm clipping surgery or arteriovenous malformation surgery.
详细描述
Patients scheduled for cerebral aneurysm clipping surgery or arteriovenous malformation surgery(ASA 1to 3 over 18years) receive standard care general anesthesia including central venous line for rapid ventricular pacing technique. A contralateral Foresight sensor is placed on the forehead of the patient at induction. After the craniotomy two micro electrodes(PBtO2 and cerebral blood flow) are placed in the brain and fixated. A subdural strip electrode is placed on the surface of the brain to record the electrical activity. Effect of mild hyperventilation and oxygenation with 100% O2 is evaluated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •scheduled for cerebral aneurysm surgery or arterial venous malformation
- •American Society of Anesthesiologists classification 1, 2, or 3
排除标准
- 未提供
结局指标
主要结局
Cerebral oxygenation during surgery
时间窗: During surgery
Oxygenation of the brain is measured by near-infrared spectroscopy and by evaluation of the brain tissue oxygen pressure by two microelectrodes placed in the brain.
Cerebral blood flow during surgery
时间窗: During surgery
Thermal diffusion flowmetry measures the local absolute cerebral blood flow
次要结局
- Electrophysiological changes in the brain during surgery(During surgery)
- Effect of ventilation with 100 % oxygen on cerebral parameters after rapid ventricular pacing(Intraoperative ( Start of ventilation at 100% oxygen until bloodgas analyses shows an increase in arterial oxygen pressure.))
- Effect of hyperventilation on cerebral parameters after rapid ventricular pacing(Intraoperative (Start of hyperventilation until bloodgas analyses shows an arterial carbon dioxide pressure between 24 and 32 millimetre of mercury.))
研究者
ethisch.comite@uza.be
Principal Investigator
University Hospital, Antwerp