NCT04707612已完成不适用
VDR SNPs & 25OHD Correlated With Dyslipidemia
Shenzhen Center for Chronic Disease Control1 个研究点 分布在 1 个国家目标入组 1,987 人开始时间: 2013年7月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,987
- 试验地点
- 1
- 主要终点
- lipid profiles
研究概览
简要总结
The project was aimed to explore the associations of single nucleotide polymorphisms (SNPs) of vitamin D receptor gene with specific circulating lipids in adult Chinese. The circulating 25-hydroxyvitamin D concentration was also tested to explore its interactions with SNPs in the associations.
研究设计
- 研究类型
- Observational
- 观察模型
- Ecologic Or Community
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 81 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •≥ 20 years old Han Chinese;
- •living in Shenzhen for > 2 years;
- •free of liver diseases, renal diseases, and any cancers in the past 6 months; and
- •not in pregnancy for women.
排除标准
- •had severe organic diseases,
- •had acute infection symptoms, allergic diseases, and malignant tumors,
- •had a family history of genetic diseases,
- •took VD supplements in the past 6 months,
- •took medicines to control lipid levels within 12 hours, or
- •took diuretics, did strenuous exercise, or overate within 24 hours before the test.
结局指标
主要结局
lipid profiles
时间窗: 6 months
Serum concentrations of TG, TC, LDLC, and HDLC
25OHD
时间窗: 6 months
Plasma 25-hydroxyvitamin D concentration
SNPs of VDR
时间窗: 6 months
Polymorphisms of vitamin D receptor gene: Cdx2, Fok1, Apa1, and Taq1
次要结局
未报告次要终点
研究者
Zhou Ji-Chang
Director of Molecular Biology Laboratory
Shenzhen Center for Chronic Disease Control
研究点 (1)
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