Attenuation of Hemodynamic response to tracheal Extubation; A comparative randomised study between esmolol and labetalol in abdominal surgeries.
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- measurement of Heart Rate, Systolic Blood Pressure , Diastolic Blood Pressure , Mean Arterial Pressure starting from time when the surgery ends till 5 minutes post tracheal extubation.
研究概览
简要总结
This is a prospective, double-blind , randomised control study to be conducted in various Operation Theatres under the Department of Anaesthesiology and Critical Care, Gauhati Medical college and hospital, Guwahati. The study will be carried out on patients of age 18 to 50 years old of both sexes posted for elective surgeries. The aim of this study is to compare the efficacy of esmolol and labetalol in attenuating hemodynamic response ( HR, SBP, DBP, MAP ) to tracheal extubation of patients undergoing General Anaesthesia. The Secondary objective of this study is to compare the hemodynamic change in Heart rate , Systolic Blood Pressure, Diastolic Blood pressure, Mean Arterial Pressure till 30 min post extubation and adverse effects if any , post administration of drug.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •patients with ASA grade 1 and 2 Patients with informed consent for the study Patients with planned abdominal surgery less than 120 minutes.
排除标准
- •Patient refusal for consent Patients with emergency surgeries Patients with ASA 3 or more Patients with bronchial asthma, Type 2 DM, Hypothyroidsm, Bleeding Diastasis, Hypertension Patients with Atrioventricular block Body mass index more than 35kg/ meter square Patients with Heart Rate less than 60/min and Blood Pressure less than 90/60 mmHg.
结局指标
主要结局
measurement of Heart Rate, Systolic Blood Pressure , Diastolic Blood Pressure , Mean Arterial Pressure starting from time when the surgery ends till 5 minutes post tracheal extubation.
时间窗: basal, at the time of reversal, at the time of giving reversal, at the time of giving drug, 1 min after giving drug, at extubation , 1 min post extubation, 3 min post extubation, 5 min post extubation
次要结局
- measurement of Heart Rate, Systolic Blood Pressure , Diastolic Blood Pressure , Mean Arterial Pressure from 5 minutes to 30 minutes post tracheal extubation.(15 minutes post extubation, 30 minutes post extubation)
- Adverse events(1 hour post extubation)
研究者
DR DHARITRI TAMULY
Department of Anaesthesia, Gauhati medical college and hospital