Effect of Passive Exercise on Systemic Endothelial Function in Elderly Patients With Chronic Heart Failure
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Endothelial function
研究概览
简要总结
The purpose of this study is to determine the effect of passive exercise on systemic endothelial function in elderly patients with chronic heart failure.
详细描述
Endothelial function is known to be impaired in patients with chronic heart failure (CHF) and impaired endothelial function has been reported to be associated with an increased mortality risk in those subjects. Although systemic exercise training has been demonstrated to improve endothelial dysfunction in patients with CHF, elderly patients with severely impaired exercise capacity could not engaged in usual exercise training using ordinal ergometer. Those patients are able to join stretching or very light resistance training. On the other hand, passive pedaling using strength ergometer has been reported to be useful in patients with severely impaired exercise capacity, but the safety and the efficacy of passive pedaling on endothelial function in old patients with CHF has not been previously reported.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of chronic heart failure
- •Elderly patients aged ≧65 years
- •Patients with severely reduced exercise capacity and cannot continue exercise with usual cycling ergometer for 5 minutes
排除标准
- •Unstable hemodynamic status (uncontrolled arrhythmia, uncontrolled congestion, uncontrolled hypertension)
- •Active infectious disease
- •Malignancy
- •Chronic obstructive pulmonary disease
- •Severe aortic valve disease
- •With any hip, knee, ankle joint pain
- •Hemiplegia
- •Current smoker
研究组 & 干预措施
1
Passive leg cycle exercise with stretching and resistance training
干预措施: Passive leg cycle exercise with stretching and resistance training (Other)
2
Stretching and resistance training
干预措施: Stretching and resistance training (Other)
结局指标
主要结局
Endothelial function
时间窗: 2 weeks
次要结局
- Six-minute walk distance(2 weeks)
- Left ventricular systolic and diastolic function(2 weeks)
研究者
Takeshi Morimoto
Investigator
Kyoto University