NCT01472471已完成不适用
Urinary 8-isoprostane is Elevated in Acute Childhood Asthma
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- We expect to see increased urinary 8-isoprostane in acute pediatric asthmatics
研究概览
简要总结
Oxidative stress is seen in children with asthma, but is hard to measure. The investigators exploring the utility of using a commercially available assay to measure oxidative stress in the urine in asthmatics. Additionally, the investigators will attempt to prove that oxidative stress is higher in children with acute asthma compared to those with stable asthma and that this stress is also higher in children with more severe clinical asthma exacerbations compared to less severe ones.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 4 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 4-18 years
- •Known stable asthmatics on no medications or with no medication changes in 3 weeks prior to enrollment
- •No asthma hospitalizations in past 3 months
- •Parent available to consent
- •Patients aged 4-18
- •Known asthmatic, admitted to Stony Brook University Hospital for status asthmaticus
- •Parent available to consent
排除标准
- •Any child with documented fever within 24 hours of study entry
- •Any child with a known current history of tracheo- or bronchomalacia
- •Any child with known clinical or laboratory evidence of shock (see below)
- •Any child with history of documented immunodeficiency, rheumatologic disease, cystic fibrosis, or renal dysfunction (see below)
- •Any child with a current or recent (less than 1 year) history of tracheostomy
- •Any child with a known genetic abnormality
- •Any pregnant child
- •Any child with a history of autism
- •Any child whose parent/caregiver is unable to give informed consent
结局指标
主要结局
We expect to see increased urinary 8-isoprostane in acute pediatric asthmatics
时间窗: Urinary 8-isoprostane levels were measured at the end of subject recruitment
次要结局
- We expect urinary 8-isoprostane levels to be higher with increased pediatric asthma severity.(This was calculated at the end of patient recruitment, after urinary 8-isoprostane levels were obtained)
研究者
研究点 (1)
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