NCT02588716已完成2 期
Effects of Terlipressin on Blood Loss and Transfusion Requirements During Major Liver Resection.
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- blood loss
研究概览
简要总结
To evaluate the effects of Terlipressin infusion on blood loss & transfusion requirements in cirrhotic patients undergoing major liver resections.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients older than 18 years of age, American Society of Anesthesiology (ASA) classification class I and II and assigned for elective resection of 2 or more liver segments portal hypertension
排除标准
- •Patients with Child-Turcotte-Pugh grade B or C, clinically significant portal hypertension (splenomegaly, thrombocytopenia with platelets < 1011/L, esophageal varices grade 2 or more), Preoperative renal failure (GFR < 50ml/min), heart failure, Bradyarrhythmia (heart rate < 60/min), history of hemorrhagic stroke, Uncontrolled arterial hypertension (Blood pressure >160/100mmHg), and Pregnancy
研究组 & 干预措施
Terlipressin
Active Comparator
Terlipressin will be given at the beginning of surgery as an initial bolus dose of (1 mg over 30 mins) followed by a continuous infusion of 2μg/kg/h to be continued throughout the surgery then gradually withdrawn over 4 hours
干预措施: Terlipressin (Drug)
Control
Placebo Comparator
same volumes of normal saline with the same rate of infusion, throughout the operation then gradually withdrawn over 4 hours.
干预措施: normal saline (Drug)
结局指标
主要结局
blood loss
时间窗: intraoperative period
blood loss in ml
次要结局
- blood units transfused(intraoperative period)
- lactate level(at start and end of resection)
研究者
Mostafa Samy Abbas
Lecturer, of Anesthesia & ICU, Assiut University
Assiut University
研究点 (1)
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