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临床试验/NCT02746588
NCT02746588已完成不适用

Description of the Uterine Cavity in Patients With Recurrent Miscarriages

Hvidovre University Hospital1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2016年2月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
100
试验地点
1
主要终点
Description of the Uterine Cavity in Patients With Recurrent Miscarriages

研究概览

简要总结

To be diagnosed with recurrent miscarriages, a couple might have a child, however experiences three or more miscarriages, primarily this happens during the first trimester.

These miscarriages often needs medical evacuation or a D & C. Surgery or retained tissue increases the risk of complications as infection and/or adhesions, known as asherman syndrome, which may result in subfertility.

Recently chronic infection in the endometrium has been proposed to contribute to the condition, as protocols including treatment with antibiotics have led to birth at term for some of these women.

Using the very minimal invasive office hysteroscopy, the investigators aim to describe the uterine cavity in patients diagnosed with recurrent miscarriages regarding both abnormalities in the endometrium and chromic infection.

详细描述

The Unit for Recurrent Pregnancy-loss at Rigshospitalet treats about 300 of couples with recurrent miscarriages a year. Together with the current examination program, the investigators plan to describe the uterine cavity according to abnormalities as septa, adhesions and further the condition for the endometrium regarding infection and hormone receptors. This description will include descriptive office hysteroscopy with biopsies for histologic - and immunohistochemically examinations.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 45 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • Correctly diagnosed with recurrent miscarriages

排除标准

  • Known course of the condition

结局指标

主要结局

Description of the Uterine Cavity in Patients With Recurrent Miscarriages

时间窗: 1 year

Observational study describing the uterine cavity in a selected patient group regarding chronic infection

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Kristine Juul Hare

MD, PhD

Hvidovre University Hospital

研究点 (1)

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