Evaluation of the cholinergic hypothesis with neurophysiological interventions such as Pupillometry and Mangina-Test in Myasthenia Gravis patients (MG)

Antonia Kaltsatou0 个研究点目标入组 66 人开始时间: 2014年3月25日最近更新: 2020年1月13日

试验速览

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•All patients were diagnosed with MG (mean time from the diagnosis was until the beginning of the study 2.9+/-0.2 years) using the established and diagnosis criteria. Specifically, their diagnosis was based on one hand on the clinical symptoms (fatigue during the day, etc), and on the other hand, on the laboratory findings (presence of positive antibodies for the AchR, positive response at the repeated stimuli test). Apart from these, MG patients showed an improvement of the muscle strength following the intake of edrophonium chloride and reacted positively to Mestinon. It was a key inclusion criterion that participants previously showed an improvement of the muscle strength following the intake of edrophonium chloride and reacted positively to Mestinon because from this we were sure that the Myasthenia Gravis Diagnosis was correct.
•All patients were free of any other neurological, ophthalmological, physical or mental disease and their visual acuity, corrected or not, were 20/20. Moreover, they had symmetrical pupils and no past history of ocular operations or diseases affecting the pupil and were not being treated at that time with anticholinergics, steroids, sympathomimetics, beta-blockers or other agents affecting the Pupil Light Reflex (PLR). Also, the basic precondition for participation was a mini mental score greater than or equal to 22. All measurements were performed between 09.00 and 10.00 hours after the participants had had a full eight-hour sleep.

•If MG patients do not show an improvement of the muscle strength following the intake of edrophonium chloride and reacted positively to Mestinon.

发起方

Antonia Kaltsatou