NCT05301790尚未招募不适用
Added Value of Breast MRI in Evaluation of Pathologic Response in Patients With Locally Advanced Breast Cancer Who Undergo Neoadjuvent Chemotherapy
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 45
- 主要终点
- comparison of MRI findings with pathologic results
研究概览
简要总结
evaluation of pathological response in breast mass by use of breast MRI in patients receiving neoadjuvent chemotherapy via comparison with pathological results
详细描述
evaluation of pathological response in locally advanced breast masses by use of breast MRI in patients receiving neoadjuvent chemotherapy via comparison with pathological results
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •all women referred to the radiology department for breast MRI examination either for screening, evaluation of suspicious lesions onsono-mammography \
- •Patients with locally advanced breast cancer
- •Patients with early stage breast cancer and chemo-responsive tumour markers (i.e. triple negative, Her2+), who will benefit from downsizing for breast conserving surgery (BCS)
- •Absolute or Relative contraindications to surgery (advanced age/multiple medical comorbidities) in the setting of estrogen receptor positive tumours (for consideration of neoadjuvant endocrine therapy)3
- •Patients must be elder than 18 years old.
- •patients with accepted renal function
排除标准
- •Patients with metastatic breast cancer.
- •Patient with breast mass more than 5 cm .
- •Patients with fungating breast mass .
- •Patients with stage IV [tumor spread to chest wall and to skin ].
- •pregnant women especially in 1th trimester.
- •Patient with presence of any paramagnetic substance as pacemakers.
- •severely ill patients .
- •patients with claustrophobia.
- •arrhythmic patients
结局指标
主要结局
comparison of MRI findings with pathologic results
时间窗: baseline
added value of breast MRI in evaluation of pathologic response in patients with locally advanced breast cancer who undergo neoadjvent chemotherapy
次要结局
未报告次要终点
研究者
Doaa Maher Ebied Maher
resident
Assiut University
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