NCT00610870已完成不适用
Effect of Atorvastatin Administration Before Primary Percutaneous Coronary Intervention in Patients With ST-segment Elevation Myocardial Infarction
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 173
- 试验地点
- 1
- 主要终点
- Myocardial infarct size by SPECT
研究概览
简要总结
The purpose of this study to determine whether statin pretreatment decrease myocardial infarct size in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Presence of chest pain for more than 30 minutes but less than 12 hours after symptom onset
- •ST segment elevation more than 1 mm in two or more contiguous leads or presumably a new onset left bundle branch blockage
排除标准
- •Cardiogenic shock
- •History of myocardial infarction
- •Chronic liver disease
- •Previous or current statin use
研究组 & 干预措施
1
Experimental
Atorvastatin group
干预措施: atorvastatin (Drug)
结局指标
主要结局
Myocardial infarct size by SPECT
时间窗: between 5 and 14 days after acute myocardial infarction
次要结局
- Myocardial infarct size measured by contrast-enhanced MRI(within 14 days after acute myocardial infarction)
- Myocardial blush grade after the procedure(immediate after procedure)
- complete ST resolution(at 60 minutes after the procedure)
- major adverse cardiac events related to left ventricular dysfunction (death, new-onset sustained hypotension or heart failure, and hospital readmission for left ventricular dysfunction)(at 6 months after the procedure)
研究者
研究点 (1)
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