Assessment of the Role of Early Urine Alkalinization and N-Acetylcysteine Administration in the Management of Hair Dye (Paraphenylene Diamine) Intoxication
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Mean difference of the serum creatinine
研究概览
简要总结
This study aimed to determine the role of early urine alkalinization and N-acetylcysteine administration for the prevention of renal damage following hair dye intoxication
详细描述
Paraphenylenediamine (PPD) is an organic compound with the formula C6H4(NH2). It is the derivative of aniline, which is a white substance that turns black on oxidation, called paraphenylaniline, which is soluble in hydrogen peroxide.
Intoxication with hair dye (PPD) has become a standard method of intentional self-harm in some parts of Africa and Asia because it is cheap and readily available in the market(5).
It can cause contact dermatitis in susceptible individuals. The glutathione (GSH) levels are depleted in PPD poisoning. The antioxidant GSH plays a vital role in the maintenance of cell viability, DNA replication, and the regulation of immune cell functions. N-acetylcysteine (NAC) acts as an antioxidant both directly as a glutathione substitute and indirectly as a precursor for glutathione.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Both sexes.
- •Patients presented acutely to the emergency department with an evident history and clinical features of hair dye intoxication
排除标准
- •Renal disease.
- •Hepatic disease.
- •Diabetes mellitus.
- •Hypertension.
研究组 & 干预措施
Study group
Patients received early N-Acetylcysteine.
干预措施: Early N-Acetylcysteine (Drug)
Control group
Patients received late N-Acetylcysteine.
干预措施: Late N-Acetylcysteine (Drug)
结局指标
主要结局
Mean difference of the serum creatinine
时间窗: Immediately after N-Acetylcysteine Administration (Up to 1 hour)
Mean difference of the serum creatinine was recorded.
次要结局
未报告次要终点
研究者
Om koulthoum Mahmoud Abozeid Soliman
Assistant Lecturer of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, South Valley University, Qena, Egypt.
South Valley University