Evaluation of Computed Tomography X-ray-Pulsatility Index (CT-XPI)
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Lung x-ray pulsatility index (XPI)
研究概览
简要总结
The goal of this clinical trial is to learn if a new computed tomography (CT) lung perfusion imaging method is as effective as standard of care (SOC) CT imaging. The main question it aims to answer is:
- Does the new contrast-free method provide more information about lung perfusion than SOC?
Participants will undergo a 30 minute chest CT.
详细描述
The purpose of the study is to evaluate X-ray Pulsatility Index using prospectively acquired dynamic CT, which is different from conventional static CT scans.
The primary objective of this study is to collect dynamic CT scan data with human participants using high frame rate imaging methods to produce a map of lung perfusion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 years or older
- •Able to sign and date the informed consent form
- •Will undergo a clinically-indicated CT exam of the head, neck, chest, abdomen, pelvis, or extremities
排除标准
- •Pregnant or lactating
- •In need of urgent or emergent care
- •Have any conditions that, in the opinion of the PI or designee, would interfere with the evaluation of the results or constitute a health hazard for the participant
研究组 & 干预措施
CT scan
Participants undergoing a CT
干预措施: CT scan (Diagnostic Test)
结局指标
主要结局
Lung x-ray pulsatility index (XPI)
时间窗: 30 minutes
XPI, a representative of lung perfusion, will be measured using CT images. The dynamic x-ray attenuation from each pixel is analyzed using spectral analysis.
Magnitude of XPI
时间窗: 30 minutes
Measured as a number, this corresponds to the magnitude of the relative change of signal.
Presence of XPI
时间窗: 30 minutes
This will be evaluated quantitatively using CNR (contrast to noise) measurements which uses a region of interest in the lungs and a region of interest outside of the lungs.
Spatial distribution of XPI signal
时间窗: 30 minutes
This is a subjective evaluation, routinely done clinically with other modalities that measure lung perfusion. Researchers evaluate how homogenous (smooth) the signal is over the lungs and look for perfusion defects (areas with little or no XPI) which would indicate pathology.
次要结局
未报告次要终点