Functional Exhaustion of T Cells in COVID19 Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- CD4+ (T-helper cells) in COVID 19 patients and healthy volunteers.
研究概览
简要总结
The primary end-point of our prospective, observational study is to count T cells in patients with laboratory-confirmed COVID-19 and healthy controls. In addition, the expression of T cell exhaustion marker was measured in COVID-19 cases.
详细描述
COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed great threat to human health. T cells play a critical role in antiviral immunity but their numbers and functional state in COVID-19 patients remain largely unclear. The immune response against viral infections depends on the activation of cytotoxic T cells that can clear infection by killing virus-infected cells, so boosting the numbers and function of T cells in COVID-19 patients is critical for successful recovery. However, the factors which might cause the reduction in count, and the activation status of T cells in COVID-19 patients, remain uninvestigated. Thus demonstration of T cell exhaustion during COVID-19 infection suggest that more urgent, early intervention may be required in patients with low T lymphocyte counts.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosis of Covid-19 test positive; hospitalized subjects; both sexes; given informed consent.
排除标准
- •no exclusion criteriae
结局指标
主要结局
CD4+ (T-helper cells) in COVID 19 patients and healthy volunteers.
时间窗: Baseline
Detection of the percentage of CD4+ (T-helper cells) in COVID 19 patients and healthy volunteers.
CD8+ (T-cytotoxic cells) in COVID 19 patients and healthy volunteers.
时间窗: Baseline
Detection of the percentage of CD8+ (T-cytotoxic cells) in COVID 19 patients and healthy volunteers .
Detect PD-1 on CD8+ and CD4+ cells in COVID 19 patients and healthy volunteers .
时间窗: Baseline
Detection of the percentage of expression of PD-1 on CD8+ and CD4+ cells in COVID 19 patient and healthy volunteers.
Detect CD28+ and CD3+ cells in COVID 19 patients and healthy volunteers.
时间窗: Baseline
Detection of the frequency of CD28+ and CD3+ cells in COVID 19 patients and healthy volunteers .
次要结局
未报告次要终点