NCT03261505已完成不适用
Mechanistic Studies on Video-guided Acupuncture Imagery Treatment of Knee Pain
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 125
- 试验地点
- 2
- 主要终点
- fMRI Signal Increases
研究概览
简要总结
The aim of this study is to investigate brain response and connectivity changes evoked by video-guided acupuncture imagery treatment (VGAIT) and verum and sham acupuncture in knee osteoarthritis patients to elucidate the underlying brain mechanisms of mind-body interaction, imagery, and acupuncture.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Right-handed
- •Knee osteoarthritis patients
- •Ages 40 to 70 years old
排除标准
- •Any contraindications to MRI scanning (claustrophobia, metal implants)
- •Current or past history of major medical, neurological, or psychiatric illness other than knee osteoarthritis (including high blood pressure, heart disorders, impaired elimination, stomach problems, major kidney or liver problems, bleeding problems, severe dehydration, history of diabetes, history of asthma or other respiratory condition)
- •Pregnancy
- •Non fluent English speaker
结局指标
主要结局
fMRI Signal Increases
时间窗: Collected once during the first treatment session
fMRI measures changes in brain activity by detecting fluctuations in blood oxygenation levels. The primary signal used in fMRI is the Blood Oxygen Level Dependent (BOLD) signal, which reflects neuronal activity indirectly through hemodynamic responses.
次要结局
- PAG Resting State Connectivity(baseline and after one month treatment)
研究者
Jian Kong
Assistant Professor
Massachusetts General Hospital
研究点 (2)
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