Effect of Prewarming on Microcirculatory Response
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Recovery Slope
研究概览
简要总结
Intraoperative hypothermia may affect tissue microcirculation and can induce myocardial injury, wound infection, and coagulopathy. During off-pump coronary artery bypass surgery without cardiopulmonary bypass or induced hypothermia, maintenance of normothermia is important for clinical outcome. The investigators hypothesized that prewarming during induction of general anesthesia would reduce drop of body temperature and change of peripheral microcirculation.
详细描述
Microcirculatory parameters can be obtained from vascular occlusion test. Among those parameters, recovery slope during vascular occlusion test is known to reflect recruitment of microvasculature in response to hypoxic or ischemic insult. In this study, we will compare the recovery slope during vascular occlusion test between prewarming treatment group and control group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 20 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •off-pump coronary artery bypass surgery
排除标准
- •refuse to enroll
- •cannot undergo vascular occlusion test: anatomical abnormality of both arms, severe peripheral vascular disease, presence of A-V fistula
- •preoperative left ventricular ejection fraction < 35%
- •preoperative continuous infusion of vasopressor or inotropes
- •pregnancy
研究组 & 干预措施
prewarming
prewarming during induction of anesthesia
干预措施: prewarming (Device)
control
no prewarming during induction of anesthesia
结局指标
主要结局
Recovery Slope
时间窗: 3 hours after induction of anesthesia
We will compare recovery slope assessed 3 hours after induction of anesthesia to evaluate the effect of prewarming during induction of anesthesia on microcirculation.
次要结局
- Tissue Oxygen Saturation(During the surgery, an average of 4 hours)