From Brain Currents to Interpersonal Flow: Investigating the Social Processing Stream of Schizophrenia
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 主要终点
- Real-world behaviour
研究概览
简要总结
The overall objective of this project is to identify the neural signature of the impaired ability to relate socially seen in individuals with schizophrenia. A hypothesized path from the neural processes of social cognition, to social cognition assessed behaviorally, to real-life social interactions is examined. Secondary aims are to compare electrophysiological measures of high vs low level social cognition; to develop assessment methods of real-life behavior; and to increase the ecological validity of schizophrenia research. Much research within the field is devoid of personal meaning and interpersonal context. This project's use of personalized assessment allows for an ecologically valid approach to the social deficits of schizophrenia.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 17 Years 至 55 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •schizophrenia
- •schizoaffective disorder
- •Exclusion Criteria
- •Hyperthyroidism
- •severe head trauma
- •neurological disease
排除标准
- 未提供
结局指标
主要结局
Real-world behaviour
时间窗: 1 day (when assessed)
Day Reconstruction Method
Real-world social interactions
时间窗: 1 day (when assessed)
Video-ethnography
Neurophysiology: ERP
时间窗: 1 day (when assessed)
ERP mentalizing paradigm (perspective taking)
Neurophysiology: EEG
时间窗: 1 day (when assessed)
EEG mu suppression paradigm using point-light displays
Social cognition: low level ToM
时间窗: 1 day (when assessed)
The Hinting Task
Social cognition: facial emotion perception
时间窗: 1 day (when assessed)
Pictures of Facial Affect
Functioning
时间窗: 1 day (when assessed)
Social Functioning Scale (SFS). Seven scales that can be combined into a total score. Mean score in a schizophrenia population = 100, SD = 15. For both the seven scales and the total score.
Cognition
时间窗: 1 day (when assessed)
Matrics Consensus Cognitive Battery
Negative symptoms: clinician-rated
时间窗: 1 day (when assessed)
Positive and Negative Syndrome Scale (PANSS) 2. Objectively assessed using computerized software (FaceReader, PRAAT) of video-taped personal narratives produced by the participants
Negative symptoms: objective 1
时间窗: 1 day (when assessed)
FaceReader
Negative symptoms: objective 2
时间窗: 1 day (when assessed)
PRAAT
Social cognition: complex ToM
时间窗: 1 day (when assessed)
Movie for the Assessment of Social Cognition
Social cognition: body language reading
时间窗: 1 day (when assessed)
Emotion in Biological Motion test
次要结局
未报告次要终点
研究者
Anja Vaskinn
Principal investigator
Oslo University Hospital