NCT03164447Unknown2 期
A Multicenter, Single-Arm, 24-Week Study of UB-421 in Combination With Optimized Background Therapy (OBT) Regimen in Patients With Multi-Drug Resistant (MDR) HIV-1 Infection
United BioPharma0 个研究点目标入组 10 人开始时间: 2023年12月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 发起方
- 入组人数
- 10
- 主要终点
- Effectiveness by Viral Load Log10 Change from Baseline
研究概览
简要总结
This is a Phase 2, multi-center study, designed to evaluate the efficacy, safety, and tolerability of UB-421 in conjunction with a failing existing ART regimen for 1 week and optimized background therapy (OBT) for 24 weeks, respectively.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Males and females, age ≥18 years;
- •HIV-1 seropositive, with documented HIV-1 infection by official, signed, written history (eg. Laboratory report);
- •Receiving a combination antiretroviral therapy (cART) (failing regimen) for at least 8 weeks before Screening and are willing to continue on the failing regimen during the Screening Phase and up to Day 14 of the Treatment Phase, OR have failed in the past 8 weeks of Screening and are off therapy and are willing to stay off therapy until Day 14 of the Treatment Phase;
- •Plasma HIV-1 RNA ≥ 1000 copies/mL at the Screening Visit and documented detectable viral load (HIV-1 RNA >200 copies/ml) within the last 3 months prior to the Screening Visit;
- •Highly treatment-experienced HIV-infected patients with documented genotypic and/or phenotypic resistance to at least one ARV drug within three or more drug classes of antiretroviral medications and have difficulty in constructing a viable suppressive regimen.
- •Have full viral sensitivity/susceptibility to at least one approved antiretroviral agent, other than UB-421, as determined by genotypic and/or phenotypic ARV drug resistance tests at screening, and such agent can be used as a component of OBT;
- •Be willing to remain on treatment without any changes or additions to the OBT regimen, except for toxicity management or upon meeting criteria for treatment failure;
- •Have a life expectancy that is > 9 months;
- •Laboratory values at Screening of:
- •Absolute neutrophil count (ANC) ≥ 750/mm3;
- •Hemoglobin (Hb) ≥ 10.5 gm/dL (male) or ≥ 9.5 gm/dL (female);
- •Platelets ≥ 75,000 /mm3;
- •Serum alanine transaminase (SGPT/ALT) < 2.5 x upper limit of normal (ULN);
- •Serum aspartate transaminase (SGOT/AST) < 2.5 x ULN;
- •Bilirubin (total) < 2.5 x ULN unless Gilbert's disease is present or subject is receiving atazanavir in the absence of other evidence of significant liver disease; and
- •Creatinine ≤ 1.5 x ULN
- •Clinically normal resting 12-lead electrocardiogram (ECG) at the Screening Visit or, if abnormal, considered not clinically significant by the Principal Investigator.
- •Both male and female patients and their partners of childbearing potential must agree to use 2 medically accepted methods of contraception (e.g., barrier contraceptives [male condom, female condom, or diaphragm with a spermicidal gel], hormonal contraceptives [implants,injectables, combination oral contraceptives, transdermal patches, or contraceptive rings], and intrauterine devices) during the course of the study (excluding women who are not of childbearing potential and men who have been sterilized). Females of childbearing potential must have a negative serum pregnancy test at the Screening Visit and negative urine pregnancy test prior to receiving the first dose of study drug; and
- •Willing and able to participate in all aspects of the study, including use of IV medication, completion of subjective evaluations, attendance at scheduled clinic visits, and compliance with all protocol requirements as evidenced by providing written informed consent.
排除标准
- •Any currently active AIDS-defining illness per Category C conditions according to the Center for Disease Control (CDC) Classification System for HIV Infection, with the following exceptions: local cutaneous Kaposi's sarcoma, wasting syndrome due to HIV or any other AIDS-defining illness for which no therapeutic treatment is required OR the required treatment is not included in the list of prohibited medications;
- •Subjects with baseline liver disease including active Hepatitis B or C infection or any other active infection secondary to HIV requiring acute therapy;
- •Subjects with baseline CD4 counts < 350 cells/mm^
- •Any ≥ Grade 3 laboratory abnormality according to the division of AIDS grading scale;
- •Unexplained fever or clinically significant illness within 2 weeks prior to the first dose of study drug;
- •Any vaccination within 2 weeks prior to the first dose of study drug;
- •Any immunomodulating therapy (excluding pre-medication steroid) or systemic chemotherapy within 4 weeks prior to the Screening Visit;
- •Any radiation therapy within 4 weeks prior to the Screening Visit;
- •Any previous exposure to monoclonal antibody for the treatment of HIV within 12 weeks prior to the Screening Visit (excluding ibalizumab);
- •Participation in an experimental drug trial(s) within 4 weeks prior to the Screening Visit;
- •Any prior exposure to UB-421;
- •Females who are pregnant, lactating, or breastfeeding, or who plan to become pregnant during the study; and
- •Any significant diseases (other than HIV-1 infection) or clinically significant findings that, in the Investigator's judgment, would potentially compromise study compliance or the ability to evaluate safety/efficacy.
研究组 & 干预措施
Multi-Drug Resistant
Experimental
干预措施: UB-421 (Biological)
Multi-Drug Resistant
Experimental
干预措施: Optimized background therapy (OBT) (Drug)
结局指标
主要结局
Effectiveness by Viral Load Log10 Change from Baseline
时间窗: 2 weeks
次要结局
- Peak concentration of UB-421(35 weeks)
- Trough concentration of UB-421(35 weeks)
- Number of participants with treatment-related adverse events(35 weeks)
研究者
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