Treatment Strategy in Patients With High-risk of Postextubation Distress in ICU Based on a Lung Ultrasound Score Versus Standard Strategy
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 483
- 试验地点
- 1
- 主要终点
- Incidence of postextubation distress
研究概览
简要总结
Prospective, randomized clinical multicentric study in ICU during weaning from mechanical ventilation.
详细描述
Prospective randomized clinical multicentric study on ICU comparing a treatment strategy (nasal humidified high flow therapy and Noninvasive Ventilation) in patients with high-risk of postextubation distress in ICU based on a Lung Ultrasound Score VERSUS standard strategy
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients ventilated more than 48 h
- •Stable respiratory and hemodynamic conditions for SBT
- •Consent of patients
- •Arterial line
排除标准
- •severe COBP
- •Laryngeal dyspnea
- •Tracheostomy
- •Arrhythmia
- •No echogenicity
- •Paraplegia >T8
研究组 & 干预措施
nasal humidified high flow therapy
Prospective randomized clinical multicentric study on ICU comparing a treatment strategy (nasal humidified high flow therapy and Noninvasive Ventilation) in patients with high-risk of postextubation distress in ICU based on a Lung Ultrasound Score VERSUS standard strategy
干预措施: lung ultrasound score (Device)
standard strategy
Prospective randomized clinical multicentric study on ICU comparing a treatment strategy (nasal humidified high flow therapy and Noninvasive Ventilation) in patients with high-risk of postextubation distress in ICU based on a Lung Ultrasound Score VERSUS standard strategy
干预措施: lung ultrasound score (Device)
结局指标
主要结局
Incidence of postextubation distress
时间窗: during 48 hour (at day 1)
postextubation period requiring a ventilatory support (reintubation or curative Noninvasive ventilation).
次要结局
- Extubation failure(at day 7)
- Number of ventilator-free-days(at day 1 (after extubation))
- Length of stay in ICU(at day 1)
- Mortality in ICU(at day 1)